ArticleJournal of the Endocrine Society2026
High protein ingestion does not affect whole-body insulin sensitivity in individuals with overweight or obesity.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss.Medical gas research · 2027Review
- Chasing the FoxO in Metabolic Disorders: Novel Considerations for Oxidative Stress, Programmed Cell Death, Wnt, and the Gut Microbiome.Antioxidants (Basel, Switzerland) · 2026Review
- High protein ingestion does not affect whole-body insulin sensitivity in individuals with overweight or obesity.Journal of the Endocrine Society · 2026Article
- Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1.Expert review of clinical pharmacology · 2026Review
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: High protein diets (HPD), rich in branched-chain amino acids (BCAAs), are proposed to enhance glycemic control. The metabolic implications of elevated BCAAs in insulin resistance (IR) are unclear, but overactivation of ribosomal protein S6 kinase B1 (S6K1)-related signaling pathway may contribute to IR. Objective: To investigate the impact of 2 dietary protein interventions on IR and molecular signaling in skeletal muscle (acutely) and adipose tissue (18-week period) in overweight/obese individuals. Methods: The acute study included ingestion of 50 g protein (MPD), 100 g protein (HPD), or 50 g of protein with added fat (MPDAF) on 3 different occasions with muscle biopsies before and after. The 18-week analysis used a subset of data with available adipose tissue biopsies from a randomized, controlled, isoenergetic dietary intervention, focusing on the relevant HPD and control diets. Insulin sensitivity was assessed using labeled intravenous glucose tolerance tests acutely, and by euglycemic-hyperinsulinemic clamp in the 18-week intervention. Results: Inositol hexakisphosphate kinase 1 (IP6K1) and total AMP-activated protein kinase (AMPK) protein content significantly decreased following the HPD meal ( Conclusion: Key proteins implicated in intracellular insulin signaling were altered with an acute HPD meal (decreased IP6K1 and AMPK, increased pAkt/Akt2 activity), indicating potential enhancement of insulin-mediated glucose signaling at the molecular level. These findings suggest that, while systemic IR was unchanged, high protein intake may have beneficial effects on cellular insulin signaling.
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