ArticleReproductive medicine and biology
Novel Insights into Normal Karyotype Miscarriage: Distinctive Patterns and Implications for Diagnosis Based on Next-Generation Sequencing Analysis.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to identify the clinical differences between normal and abnormal karyotype miscarriages and evaluate whether clinical findings could predict the presence or absence of chromosomal abnormalities. Methods: A total of 117 patients with early miscarriage who underwent chorionic villus chromosomal testing using next-generation sequencing were retrospectively analyzed. Clinical findings were compared between the normal (euploid; Results: Normal karyotype miscarriages occurred significantly more often before yolk sac visualization (29.8% vs. 0%, Conclusion: Distinct clinical and ultrasonographic patterns were observed in normal and abnormal karyotype miscarriages. These features have limited diagnostic value, and their usefulness in supporting counseling or decision-making is also limited when genetic testing is not available.
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