ArticleMultiple sclerosis journal - experimental, translational and clinical
Eye movement analysis during working memory tasks correlates with cognitive, clinical, and anatomical metrics in multiple sclerosis.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cognitive dysfunction involving working memory is common in multiple sclerosis (MS) but is often under-detected in clinical assessments. Noninvasive digital biomarkers like oculomotor metrics may enhance the detection of neurofunctional changes. Objective: Determine whether oculomotor metrics during a visuospatial Methods: In a cross-sectional study, 38 patients completed an Results: Gaze duration and task accuracy were inversely correlated (r = -0.57, p < 0.001). Shorter gaze duration and higher task accuracy, indicators of better cognitive processing efficiency, were associated with better SDMT scores, greater RNFL thickness and macular volume, and better EDSS and 9HPT completion times. Conclusions: Oculomotor metrics recorded during a working memory task are associated with cognitive, retinal, and functional measures in pwMS, supporting their potential as noninvasive biomarkers to complement standard clinical assessments in detecting cognitive dysfunction.
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