ArticleJournal of inflammation research2026
A Cohort Study on Systemic Immune-Inflammation Index and Its Longitudinal Change in Relation to Colorectal Adenoma Recurrence.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Objective: This study aimed to investigate the associations of both baseline systemic immune-inflammation index (SII) and, more importantly, its longitudinal change (ΔSII) during follow-up with the risk of advanced colorectal neoplasia (ACRN) recurrence after endoscopic resection of colorectal adenomas. Methods: Clinical data from 1855 patients diagnosed with colorectal adenomas and undergoing resection at Hospital between January 2017 and August 2023 were analyzed. Patients were classified into Q1-Q4 groups based on baseline SII quartiles and into three groups according to ΔSII. Cox proportional hazards regression models, restricted cubic spline (RCS) analysis, Kaplan-Meier curves, receiver operating characteristic (ROC) curve, subgroup analysis, sensitivity analyses were used to evaluate associations. Results: After an average follow-up of 3.4 years, 166 patients (8.95%) experienced ACRN recurrence. After fully adjusting for variables, Cox proportional hazards regression analysis revealed that the group with the highest baseline SII (Q4) had a 1.75-fold increased risk of ACRN recurrence compared to Q1 (HR, 1.75; 95% Conclusion: Not only baseline SII but also ΔSII during follow-up serves as a significant and independent predictor for ACRN recurrence. Monitoring the longitudinal change of SII may provide incremental clinical value for optimizing personalized surveillance strategies after endoscopic resection.
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