Evidence map›Paper›PMID 42131727›Full record

ArticleAlzheimer's & dementia. Behavior & socioeconomics of aging2025

Functional ability in cognitive complaints: The role of neuropsychiatric and cognitive factors in community-dwelling older adults.

Gonzalo Forno, Pedro Zitko, Patricia Lillo, Daniela Thumala, Fernando Henriquez, Adolfo M Garcia, Mauricio Cerda, Agustin Ibañez, David Martinez-Pernia, Eneida Mioshi and 3 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia. Behavior & socioeconomics of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gonzalo FornoGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Pedro ZitkoGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Patricia LilloGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Daniela ThumalaGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Fernando HenriquezGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Adolfo M GarciaCentro de Neurociencias Cognitivas, Universidad de San Andrés, Vito Dumas 284 (B1644BID), Victoria, Provincia de Buenos Aires, Argentina.
Mauricio CerdaGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Agustin IbañezLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
David Martinez-PerniaGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Eneida MioshiFaculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Michael HombergerClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.
Mauren Schmitter-EdgecombeDepartment of Psychology, Washington State University, Pullman, WA, USA.
Andrea SlachevskyGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Circadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0M
NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG083799
6 · The paper itself

Abstract

introcutionThe relationship between functional ability and neuropsychiatric or cognitive factors in older adults with cognitive complaints (CCs) remains unexplored in Latin America.

methods290 community-dwelling older adults with CCs were recruited. Multiple regression analyzed the association between activities of daily living (ADLs) and neuropsychiatric and cognitive factors. Variance proportion in ADLs were further explored.

resultsApathy was associated with reduced functional ability (T-ADLQ global score [β = -0.42, 95% CI -0.57, -0.28]). Depression was linked to impaired advanced ADLs (β = 0.94, 95% CI 0.09, 1.79) and basic ADLs (β = 0.22, 95% CI 0.03, 0.42). Naming and speeded processing were significantly associated with global ADLs ((β = -0.55, 95% CI -0.99, -0.12); (β = 0.26, 95% CI 0.04, 0.48), respectively) and distinct ADLs sub-scores. DISCUSSION: Neuropsychiatric and cognitive factors affect ADLs based on their complexity. These results call for targeted interventions supporting independence in Latin American older adults.

Indexed as

cognitive complaintcognitive factorsCommunity-dwellingfunctional abilityLACneuropsychiatric symptoms

Identifiers

PMID42131727
PMCPMC13166970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.