Evidence map›Paper›PMID 42131687›Full record

ArticleHuman population genetics and genomics2026

Xiran Liu, Noah A Rosenberg, Sohini Ramachandran

Abstract read
In one paragraph

Article in Human population genetics and genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Human population genetics and genomics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiran LiuData Science Institute, Brown University, Providence, RI, 02912, USA.
Noah A RosenbergDepartment of Biology, Stanford University, Stanford, CA, 94305, USA.
Sohini RamachandranData Science Institute, Brown University, Providence, RI, 02912, USA.

Funding

Population genetics for large-scale sequencing studies of diverse populationsR01HG005855 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Noah Rosenberg, Paul A Scheet · 2010 to 2026
$5.8M
Population-genetic methods for inferring recent histories and targets of selection in the biobank eraR35GM139628 · NIGMS · BROWN UNIVERSITY · PI Sohini Ramachandran · 2021 to 2026
$2.2M
NHGRI NIH HHS R01 HG005855NIGMS NIH HHS R35 GM139628
6 · The paper itself

Abstract

We previously introduced Clumppling to address the "alignment problem" for multiple mixed-membership unsupervised clustering results in population structure analyses, where clusters represent latent genetic ancestries. This problem stems from three challenges-label-switching, multi-modality, and varying numbers of clusters-which Clumppling resolves in three steps: aligning results with the same number of clusters, detecting distinct solutions or "modes," and aligning modes across different numbers of clusters. Here, we present Clumppling 2.0, an update with features for visualizing the emergence of clusters, comparing aligned results from different models, and incorporating modularity of algorithmic steps. We outline the Clumppling 2.0 workflow, highlighting its improved algorithmic flexibility and visual interpretability through a graph of alignment patterns. We then demonstrate its utility on human genetic datasets that include individuals from admixed populations.

Indexed as

admixturealignmentclusteringgenetic ancestrypopulation structure

Identifiers

PMID42131687
PMCPMC13167144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.