ArticleCureus2026
Infection of a Total Femur Megaprosthesis: A Retrospective Study of Clinical and Functional Outcomes.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
introductionInfection associated with total femur megaprostheses represents an uncommon and highly complex clinical scenario, typically occurring in patients with multiple previous surgeries and massive bone loss. Evidence regarding outcomes in non-oncologic indications remains limited.
methodsA retrospective study was conducted, including patients treated with total femur megaprosthesis for prosthetic joint infection at Hospital Universitari i Politècnic La Fe, a tertiary referral center in Valencia, Spain, between 2016 and 2023. Clinical, microbiological, and outcome data were collected from medical records. An exploratory analysis was performed, comparing patients with favorable and unfavorable outcomes using non-parametric tests.
resultsTen patients were included, with a mean age of 69 years and a median of six previous surgical procedures. Comorbidities included diabetes mellitus (30%), immunosuppression (40%), and rheumatic disease (20%). The microbiological spectrum was heterogeneous, with
conclusionsTotal femur megaprosthesis in septic settings is a salvage procedure that may allow limb preservation in highly complex patients, although it is associated with a high complication rate and limited functional outcomes. Its use should be restricted to selected cases and specialized centers. Further multicenter studies are needed to optimize patient selection and management strategies.
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