ArticleFrontiers in medicine2026
The clinical observation of ciprofol versus propofol anesthesia in hysteroscopic electrosurgical resection of submucosal myomas.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To evaluate the clinical efficacy of ciprofol versus propofol combined with alfentanil for anesthesia in patients undergoing hysteroscopic transcervical resection of submucosal myomas. Methods: A total of 208 patients scheduled for hysteroscopic transcervical resection of submucosal myomas were randomly allocated into ciprofol (group C) and propofol (group P) groups after exclusion. All patients received intravenous alfentanil 10 μg/kg before induction. The group C received intravenous ciprofol 0.4 mg/kg, while the group P received intravenous propofol 2.0 mg/kg. After anesthesia induction, a laryngeal mask airway was inserted. Anesthesia was maintained with a continuous infusion of ciprofol 0.8 mg/(kg·h) or propofol 5 mg/(kg·h) using a micro-infusion pump until the end of surgery. Mean arterial pressure (MAP), heart rate (HR), and bispectral index (BIS) were recorded at the following time points: Pre-anesthesia (T0), after anesthesia induction (T1), during cervical dilation (T2), during electrosurgical resection (T3), and at the end of surgery (T4). Total dosage of study drug, recovery time, orientation recovery time, visual analogue scale (VAS) scores for uterine contraction pain after awakening, and adverse events were recorded. Results: Intraoperative decreases in MAP and HR were significantly greater in the group P than in the group C ( Conclusion: Ciprofol exhibits comparable efficacy to that of propofol. It has good analgesic activity, more stable hemodynamics, and minimal respiratory disturbance, less injection pain rate in hysteroscopic transcervical resection of submucosal myoma.
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