Evidence map›Paper›PMID 42131503›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Therapeutic potential of recombinant human collagen XVII in blue light-induced skin photoaging: preserving epidermal-dermal structural integrity and functional homeostasis.

Xudong Wang, Linlin Zhang, Qiang Li, Junhong Ao, Xin Zhang, Xin Yang, Jijin Li, Shijia Sui, Ge Ge, Haitao Li and 1 more

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xudong Wang *Department of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Linlin Zhang *Department of Dermatology, Shanghai Huamei Aesthetic and Cosmetic Hospital, Shanghai, China.
Qiang LiMedical Health Care Department, Air Force Medical Center PLA, Beijing, China.
Junhong AoDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Xin ZhangDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Xin YangDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Jijin LiDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Shijia SuiDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Ge GeDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Haitao LiDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Rongya YangDepartment of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Excessive exposure to blue light (BL) contributes to skin photoaging by inducing oxidative stress, inflammation, extracellular matrix degradation, and disruption of epidermal-dermal integrity. Recombinant human type XVII collagen (rhCol17) is a bioactive material with high biocompatibility and reported roles in tissue repair. However, its protective effects against BL-induced photoaging remain unclear. Methods: Results: Conclusion: These findings suggested that rhCol17 protects against BL-induced molecular damage and functional impairment in epidermal and dermal cells, while maintaining epidermal-dermal structural integrity. rhCol17 represents a promising therapeutic strategy for preventing BL-related skin damage and offers preliminary insights for potential clinical translation.

Indexed as

blue lightfibroblastkeratinocytephotoagingrecombinant human collagen XVII

Identifiers

PMID42131503
PMCPMC13161066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.