ArticleTzu chi medical journal
Serum adipocyte fatty acid-binding protein is associated with impaired endothelial function in nondialysis chronic kidney disease.
Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Adipocyte fatty acid-binding protein (A-FABP) has been implicated in atherosclerosis, and endothelial dysfunction is a critical contributor to cardiovascular outcomes in chronic kidney disease (CKD). This study evaluated links between serum A-FABP and endothelial function among patients with CKD who were not on dialysis. Materials and Methods: Fasting serum from 151 adults with CKD not on dialysis was analyzed for A-FABP using enzyme immunoassay. Endothelial function was measured noninvasively through digital thermal monitoring (DTM), yielding vascular reactivity index (VRI) scores categorized as poor (<1.0), intermediate (1.0-1.99), or good (≥2.0) vascular reactivity. Results: Vascular reactivity categorized by DTM-derived VRI was poor in 17.9% ( Conclusion: Higher serum A-FABP independently correlated with reduced VRI, consistent with a potential modulatory role and supporting its use as a biomarker of endothelial dysfunction in nondialysis CKD patients.
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