ArticleTzu chi medical journal
Human leukocyte antigen study on a cohort of 149 Vietnamese umbilical cord blood samples.
Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: We here report the distribution of the human leukocyte antigen (HLA)-A, -B, -C, -DRB1, and -DQB1 alleles among 149 units of Vietnamese umbilical cord blood samples and deduced their most probable HLA haplotypes for HLA-A/B loci, HLA-B/C loci, HLA-DRB1/DQB1 loci, HLA-A/C/B loci, HLA-A/C/B/DRB1 loci, and HLA-A/C/B/DRB1/DQB1 loci. Our objective is to reveal the unprecedented information on the distribution of HLA alleles in the Vietnamese cord blood and to find out the most probable HLA haplotypes associated with the various HLA alleles detected in the cohort of 149 cord blood specimens. Materials and Methods: The material for this study was umbilical cord blood samples, preserved in acid citrate dextrose anticoagulants. The blood donors were umbilical cord blood donors whose parents voluntarily donated their newborn baby's cord blood to the Blood Transfusion and Hematology Hospital, Ho Chi Minh City, Vietnam. DNA sequence-based typing of the Sanger's sequencing method was performed for the HLA allelic typing. Target exon sequence amplifications were achieved by polymerase chain reaction (PCR), and the resulting amplicons were sequenced by BigDye Terminator Cycle Sequencing Ready Reaction Kit, according to the manufacturer's protocols. Results: In the total number of 149 randomized cord blood samples studied, we detected distinctive 22 HLA-A alleles, 23 HLA-C alleles, 44 HLA-B alleles, 27 HLA-DRB1 alleles, and 15 HLA-DQB1 alleles. In addition, we determined the most probable HLA haplotypes for the alleles detected. Conclusion: Our findings in this study are useful in research for the comprehensive understanding of the distribution of HLA alleles and their associated HLA haplotypes in Vietnamese cord blood. Further, the cord blood with HLA typing determined is now ready for matching search purpose for patients who are looking for suitable hematopoietic stem cell donations for transplantation therapeutic applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.