ArticleJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2026
Penicillin allergies and community antibiotic prescriptions: A secondary analysis of prescribing choices in six family medicine clinics in southern Ontario, 2018-2019.
Article in Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While 10% of the population has a reported penicillin allergy, 90% of these allergy labels may not be accurate. However, the impact of penicillin allergy de-labelling on antibiotic use in primary care is not clear. We aimed to determine the effect of penicillin allergy labels on antibiotic use in the community for common infections. Methods: A secondary analysis of cross-sectional data from a previous stewardship intervention study in six family medicine clinics in southern Ontario was conducted. Antibiotic prescriptions to 914 adult patients presenting with common respiratory and urinary tract infections from 2018 to 2019, with and without a penicillin allergy in their electronic medical record, were examined. The primary outcome was what antibiotics were prescribed to patients with and without a penicillin allergy. Results: Of 914 patients included, 84 (9.2%) had a penicillin allergy listed in their medical record. Penicillin allergy labels affected prescribing for acute respiratory infections, with patients more commonly prescribed macrolides ( Conclusions: Antibiotic prescribing choices were affected by penicillin allergy labels, with more frequent prescribing of broad-spectrum antibiotics, particularly in acute respiratory infections. However, the proportion of all antibiotic prescriptions that would be changed by penicillin de-labelling was small. Other antimicrobial stewardship approaches in addition to penicillin allergy de-labelling may be needed to reduce antibiotic overuse in primary care.
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