Evidence map›Paper›PMID 42131331›Full record

ArticleFrontiers in immunology2026

sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney disease.

Xushun Jiang, Wenge Huang, Wen Wen, Ting Liu, Wei Ren, Jia Shi, Junling He, Xiaogang Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xushun Jiang *Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenge Huang *Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wen WenDepartment of Nephrology, Metabolism and Immunology Laboratory for Urological Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ting LiuDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wei RenDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jia ShiHealth Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Junling HeHealth Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaogang DuHealth Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is a key driver of diabetic kidney disease (DKD) progression, with the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome representing a promising therapeutic target. Soluble epoxide hydrolase (sEH), an enzyme that inactivates renoprotective epoxyeicosatrienoic acids into less active diols, has been implicated in renal pathophysiology. This study investigated the role of sEH in renal tubular NLRP3 inflammasome activation and its underlying mechanisms in DKD. We observed upregulated sEH expression in high glucose (HG)-stimulated human proximal tubular epithelial (HK-2) cells and diabetic kidneys. Pharmacological inhibition of sEH attenuated diabetes-induced mitochondrial damage, mitochondrial reactive oxygen species (mtROS) production, NLRP3 inflammasome activation, and renal dysfunction both

Indexed as

Diabetic NephropathiesEpithelial CellsEpoxide HydrolasesInflammasomesMitophagyNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesAnimalsCell LineHumansKidney TubulesKidney Tubules, ProximalMaleMiceMitochondriaEpoxide HydrolasesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanReactive Oxygen Speciesdiabetic kidney diseasemitochondrial reactive oxygen speciesmitophagyNLRP3 inflammasomesoluble epoxide hydrolase

Identifiers

PMID42131331
PMCPMC13160782

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.