ArticleFrontiers in immunology2026
Markers of inflammation and lung function in liver transplant recipients: results from a nationwide cohort study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: In the general population elevated circulating inflammatory markers have been associated with impaired lung function in cross-sectional and longitudinal studies. No studies have investigated this association in liver transplant recipients, and we aimed to investigate if elevated inflammatory markers were associated with impaired lung function in this population. Methods: Adult liver transplant recipients from The Danish Comorbidity in Liver Transplant Recipients (DACOLT) study, with available spirometry, high sensitivity (hs)-CRP, interleukin (IL)-1β, IL-2, IL-6, IL-10, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α were included. Outcomes were forced expiratory volume in one second (FEV Results: We included 335 liver transplant recipients. The prevalence of airflow limitation and PRISm was 11.6% and 24.5%, respectively. The median FEV Conclusion: Elevated hs-CRP was associated with impaired lung function indicating that systemic inflammation may be part of the pathophysiology of impaired lung function in liver transplant recipients.
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