ArticleFrontiers in cellular and infection microbiology2026
Antifungal efficacy of a novel nitric oxide releasing solution in the presence of keratin.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Novel Nitric Oxide-Releasing Formulations Show Fungicidal Potential for Superficial Dermatophyte Infection.Journal of fungi (Basel, Switzerland) · 2026Article
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Authors and funding
8 authors.
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Abstract
Introduction: Nitric oxide (NO)-based therapeutics represent a promising modality for overcoming the challenges of treating dermatophyte infections within keratinized tissues. Methods: This study evaluated the antifungal activity of a nitric oxide-releasing solution (NORS) against clinical isolates of Trichophyton mentagrophytes, Trichophyton tonsurans, and Epidermophyton floccosum, comparing MIC and MFC profiles to efinaconazole and assessing keratin associated inhibition relative to terbinafine. Results: NORS demonstrated potent fungicidal activity across all species, with MIC90 and MFC90 values consistently at 0.005 μg/mL. Unlike terbinafine, whose efficacy decreased significantly in keratin-rich environments, NORS retained antifungal activity in the presence of human nail keratin. Discussion: These results support further clinical evaluation of NO-based antifungals as potential treatments for onychomycosis and tinea pedis.
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