Bacteriophage Intervention in Pseudomonas aeruginosa-Induced Corneal Ulceration: A Multifaceted Study Assessing Therapeutic Efficacy in Surrogate Bacterial and Animal Models.

Aalok Kumar, Lavanya Anuranjani, Mayank Gangwar, Arup Dey, Gopal Nath

Abstract read

In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aalok KumarDepartment of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

Lavanya AnuranjaniDepartment of Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

Mayank GangwarDepartment of Development Research, Clinical Studies and Trial Unit, Indian Council of Medical Research (ICMR), New Delhi, IND.

Arup DeyDepartment of Pharmaceutical Technology, School of Health and Medical Science, Guwahati, IND.

Gopal NathDepartment of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of our study was to learn about the effect of bacteriophages derived from the water of the river Ganga on MATERIAL AND

methodsWe used a mouse model for this study. The most potent phages targeting

resultsThe results yielded significantly improved disease outcomes. The treatment not only preserved the structural integrity and transparency of the infected cornea but also suppressed neutrophil infiltration and bolstered bacterial clearance, as evidenced by histopathological analysis.

conclusionThese findings suggest that bacteriophage therapy can be an effective alternative therapeutic approach for treating antibiotic-resistant infectious keratitis. Also, we can use bacteriophages in combination with antibiotics already in use.

Indexed as

bacteriophage therapycorneal ulcerationpseudomonas aeruginosa (p. aeruginosa)rat model studytherapeutic intervention efficacy

Identifiers

PMID42131249

DOI10.7759/cureus.108721

PMCPMC13165683

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