ReviewFrontiers in nutrition2026
Gut microbiota and pediatric eye diseases: current insights, mechanistic underpinnings, and future outlook.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Short-Chain Fatty Acids: Microbial Metabolites Driving Gut-Eye Axis Signaling.Comprehensive physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As a core component of the human microecosystem, the gut microbiota modulates systemic immune-inflammatory responses, metabolic homeostasis, and neural signal transmission via the gut-eye axis. Dysbiosis of the gut microbiota has been closely linked to the onset and progression of multiple ophthalmic disorders in adults. Childhood represents a critical window for both gut microbial colonization and maturation, as well as a formative period for ocular development and visual function establishment. Objective: This review systematically examines the evidence connecting gut microbiota to several common pediatric ophthalmic diseases, including allergic conjunctivitis, myopia, retinopathy of prematurity, and postoperative inflammation following congenital cataract surgery. Methods: We conducted a narrative literature review analyzing the potential mechanisms underlying the gut-eye axis, including immune regulation, microbial metabolite signaling, crosstalk between the intestinal barrier and blood-ocular barrier, and neural pathways. A comprehensive search of PubMed, Web of Science, and Scopus databases was performed for literature published from January 2000 to October 2025 using search terms related to gut microbiota and pediatric ophthalmic diseases. Studies were selected based on clinical relevance and contribution to understanding gut-eye axis interactions in pediatric populations. Results: The review identifies emerging associations between gut microbiota dysbiosis and various pediatric ophthalmic conditions, with evidence supporting immune dysregulation, metabolite imbalance, and barrier dysfunction as potential mechanistic pathways. Conclusion: Early disruptions to the gut microbiota may exert potential long-term effects on ocular health. This review aims to provide new insights into the etiology, early intervention, and precision management of pediatric ophthalmic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.