Trial reportFrontiers in nutrition2026
Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/objectives: The skin is the largest organ of the human body and undergoes age-related changes, such as reduced hydration, loss of elasticity, and wrinkle formation, which can affect appearance and quality of life. Piceatannol has antioxidant and anti-inflammatory properties and has attracted attention as a functional ingredient for maintaining skin health. The current study aimed to evaluate the effects of piceatannol intake on skin hydration and the severity of wrinkles. Methods: In a randomized, double-blind, placebo-controlled trial, healthy Japanese women aged 30-59 years were made to ingest a drink containing 10 mg of piceatannol derived from passion fruit seeds, or a matching placebo, once daily for 8 weeks. Stratum corneum hydration, and wrinkle grades were assessed at baseline and at the end of the treatment. Results: Eighty-six participants were enrolled in the trial and 82 participants were included in the analysis. The piceatannol group exhibited a statistically significant increase in facial stratum corneum hydration compared to the placebo group. In addition, wrinkle grades showed that wrinkles improved significantly in the piceatannol group compared to in the placebo. Conclusion: Intake of piceatannol could serve as an effective dietary intervention for improving skin hydration and wrinkles. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000064440, identifier UMIN000056580.
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