Evidence map›Paper›PMID 42131216›Full record

ArticleLung Cancer (Auckland, N.Z.)2026

Exploratory Identification of Gene Copy Number Cut-Off for NGS-Based

Si-Yang Maggie Liu, Zhi Xie, Lixu Yan, Guang-Ling Jie, Jia-Yi Deng, Qingling Zhang, Zhan Huang, Jin Wang, Zhou Zhang, Yang Shao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung Cancer (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Si-Yang Maggie LiuGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.ORCID 0000-0002-3837-0758
Zhi XieGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Lixu YanDepartment of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Guang-Ling JieGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Jia-Yi DengGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Qingling ZhangDepartment of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Zhan HuangDepartment of Translational Medicine, Amoy Diagnostics, Xiamen, People's Republic of China.
Jin WangDepartment of Translational Medicine, Amoy Diagnostics, Xiamen, People's Republic of China.
Zhou ZhangData Science Department, Burning Rock Biotech, Guangzhou, People's Republic of China.
Yang ShaoGeneseeq Research Institute, Nanjing Geneseeq Technology Inc, Nanjing, People's Republic of China.
Hao MengDepartment of Bioinformatics, Berry Oncology Institute, Beijing, People's Republic of China.
Yan ZhangDepartment of Data Interpretation, Geneplus-Beijing Institute, Beijing, People's Republic of China.
Xu-Chao ZhangGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Hua-Jun ChenGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Wen-Zhao ZhongGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Qing ZhouGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.ORCID 0000-0002-0478-176X
Yi-Long WuGuangdong Lung Cancer Institute, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.ORCID 0000-0002-3611-0258

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: This was a multiple-site joint study to optimize the cut-off value for Results: In the training cohort (n=21), the optimal Conclusion: In this study, an exploratory cut-off of 6.55 for

Indexed as

gene copy numberMET amplificationnext-generation of sequencingnon-small-cell lung cancertargeted therapy

Identifiers

PMID42131216
PMCPMC13165478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.