Evidence map›Paper›PMID 42131200›Full record

ArticleFrontiers in microbiology2026

Effect of biofilm formation on the antimicrobial activity of tigecycline against

Hyunseo Park, Sara E Maloney Norcross, Anthony J Hickey, Mercedes Gonzalez-Juarrero, Bernd Meibohm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyunseo ParkDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, United States.
Sara E Maloney NorcrossEngineering and Advanced Technology Department, RTI International, Durham, NC, United States.
Anthony J HickeyEngineering and Advanced Technology Department, RTI International, Durham, NC, United States.
Mercedes Gonzalez-JuarreroMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.
Bernd MeibohmDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, United States.

Funding

Inhaled tigecycline therapy for pulmonary M. abscessus infectionsR01AI155922 · NIAID · COLORADO STATE UNIVERSITY · PI GONZALEZ-JUARRERO, MERCEDES, MALONEY, SARA ELIZABETH · 2021 to 2025
$3.6M
Mass Spectrometer for Small Molecule Drug DevelopmentS10OD016226 · OD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MEIBOHM, BERND · 2014 to 2014
$316k
NIAID NIH HHS R01 AI155922NIH HHS S10 OD016226
6 · The paper itself

Abstract

Introduction: Due to the inherent drug-resistance mechanisms and biofilm formation of Methods: This study aimed to define the exposure-response relationship of tigecycline in Results: Dynamic time-kill assays conducted using the hollow fiber system, which mimicked tigecycline lung exposure under diverse intrapulmonary aerosol administration scenarios, demonstrated that high exposure to tigecycline effectively killed Discussion: A quantitative assessment of the impact of these factors modulating the bacterial pathophysiology provides insights into how

Indexed as

biofilmhollow fiber infection modelMycobacterium abscessusnon-tuberculous mycobacteriaPK/PDtigecycline

Identifiers

PMID42131200
PMCPMC13161170

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.