Evidence map›Paper›PMID 42131168›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2026

Clinical and Demographic Predictors of Optic Neuritis Subtype.

Noreen F Khan, Etienne Benard-Seguin, Derek Waldner, Abdullah Al-Ani, Lizbeth Gonzalez, Patrice M Hicks, Yue Pan, Fiona Costello, Lindsey B De Lott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Noreen F KhanDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Etienne Benard-SeguinCumming School of Medicine, Departments of Surgery (Ophthalmology), University of Calgary, Calgary, Alberta, Canada.
Derek WaldnerCumming School of Medicine, Departments of Surgery (Ophthalmology), University of Calgary, Calgary, Alberta, Canada.
Abdullah Al-AniCumming School of Medicine, Departments of Surgery (Ophthalmology), University of Calgary, Calgary, Alberta, Canada.
Lizbeth GonzalezDepartments of Surgery (Ophthalmology), Department of Ophthalmology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Patrice M HicksDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Yue PanDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Fiona CostelloCumming School of Medicine, Departments of Surgery (Ophthalmology), University of Calgary, Calgary, Alberta, Canada.
Lindsey B De LottDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine which clinical features differentiate acute optic neuritis (ON) subtypes to support treatment decision-making in patients when the diagnostic work-up is incomplete or inconclusive. We performed a retrospective study at two academic centers. ON was classified as idiopathic/multiple sclerosis-associated (I/MS-ON; also known as "typical" ON) versus non-I/MS-ON (e.g. neuromyelitis optica; also known as "atypical" ON). Multiple linear regression models assessed the association between ON subtype and clinical features including: demographics, presence of optic disc edema, bilaterality (simultaneous ON involving both eyes), and baseline visual acuity (logMAR). Sensitivity analyses examined the impact of incomplete race/ethnicity data on subtype. Among 614 episodes (518 patients), most ON events (

Indexed as

decision-makingOptic neuritispredictorssteroid-responsivenesstreatment

Identifiers

PMID42131168
PMCPMC13166227

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.