B-Cell Acute Lymphoblastic Leukemia Relapse Presenting as Choroidal Infiltration Confirmed by Choroidal Biopsy Along with Ipsilateral Optic Nerve Involvement.

Brandon Bates, Damodaran Narayanan, Raven Cooksey, Moe Hein Aung, Shelley Day Ghafoori

Abstract readCase Reports

In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brandon BatesMitchel and Shannon Wong Eye Institute, Department of Ophthalmology, Dell Medical School at the University of Texas at Austin, Austin, Texas, USA.

Damodaran NarayananPathology, Clinical Pathology Associates, Austin, Texas, USA.

Raven CookseyOncology, Dell Children's - Children's Blood and Cancer Center Specialty Pavilion, Austin, Texas, USA.

Moe Hein AungMitchel and Shannon Wong Eye Institute, Department of Ophthalmology, Dell Medical School at the University of Texas at Austin, Austin, Texas, USA.

Shelley Day GhafooriMitchel and Shannon Wong Eye Institute, Department of Ophthalmology, Dell Medical School at the University of Texas at Austin, Austin, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case that describes the relapse of histopathologically confirmed B-cell acute lymphoblastic leukaemia (B-ALL) in a 21-year-old male who presented with monocular subacute vision loss, photopsia, and floaters. His exam was notable for optic disc oedema and peripapillary choroidal thickening. He underwent trans-retinal choroidal biopsy where B-ALL recurrence was confirmed, and external beam radiation was initiated. This case demonstrates how choroidal biopsy can assist with establishing the diagnosis of ALL relapse in clinically atypical cases. ALL relapse isolated to the optic nerve and choroid is rare but should be considered in patients with appropriate medical history. Prompt diagnosis and initiation of treatment can yield excellent visual recovery, prevent irreversible vision loss, and potentially avert systemic relapse.

Indexed as

B-cell acute lymphoblastic leukaemiainfiltrative optic neuropathyoptic nerve oedemaoptic neuropathytransretinal choroid biopsy

Identifiers

PMID42131156

DOI10.1080/01658107.2025.2526040

PMCPMC13166241

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.