ReviewJournal of otology2026
EEG Spectral Analysis of Tinnitus Sound Therapy: Meta-Analysis.
Review in Journal of otology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic subjective tinnitus affects 15-20% of adults globally, with 3-5% experiencing severe quality-of-life impairment. Sound therapy (ST) is a core intervention, but its neuromodulatory mechanisms remain incompletely characterized due to the lack of objective biomarkers. Methods: Following PRISMA guidelines, we systematically searched PubMed, Web of Science, Embase, and other databases (1977-2025) for randomized controlled trials (RCTs) investigating ST effects on EEG spectral power in tinnitus patients. Inclusion criteria required pre/post-ST EEG data in delta (0.5-4 Hz) and alpha (8-14 Hz) bands. Two independent reviewers extracted data and assessed bias using Cochrane tools. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled via fixed/random-effects models. Results: Two RCTs (n=71 patients) met inclusion criteria. Post-ST, the intervention group showed non-significant trends toward increased delta (SMD=0.11, 95% CI: [-0.40, 0.62], P=0.67) and alpha (SMD=0.09, 95% CI: [-0.41, 0.60], P=0.72) power. Between-group analyses revealed greater alpha enhancement in customized ST versus controls (SMD=0.40, 95% CI: [-0.12, 0.91], P=0.13; I Conclusion: ST induces measurable delta/alpha power modulation, suggesting enhanced inhibitory neurotransmission and attentional regulation. While statistical significance was limited by sample size, these trends support EEG as a tool for objective treatment monitoring. We propose a "dual-band synergistic neuromodulation" framework: ST concurrently suppresses pathological hyperexcitability and potentiates slow-wave inhibition. Standardized EEG protocols and longitudinal validation are critical for advancing precision tinnitus therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.