ReviewFrontiers in cardiovascular medicine2026
Maternal-fetal microRNA axis in congenital heart disease: implications for tetralogy of Fallot.
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modelling Tetralogy of Fallot: insights and limitations of animal models.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tetralogy of Fallot (ToF), accounting for 7%-10% of congenital heart defects, represents the most prevalent cause of cyanotic CHD and is increasingly recognized as a lifelong condition characterized by progressive right ventricular (RV) dysfunction and heart failure. Objective: Since genetic variants explain only a minority of cases, this minireview highlights the role of microRNAs (miRNAs) as important epigenetic regulators in ToF pathogenesis. Methods: By integrating evidence from in silico bioinformatic pipelines, Results: Bioinformatic investigations have revealed extensive miRNome reprogramming, identifying master regulators such as miR-124, miR-222, and miR-1275 that converge on critical pathways involving inflammation, ferroptosis, and metabolic adaptation. Complementary, Conclusions: Despite these advances, the causal relationships and temporal dynamics of miRNA regulation remain largely unresolved. Future integrative longitudinal studies and functional validations are essential to translate these epigenetic insights into novel biomarkers and targeted therapeutic interventions, ultimately improving long-term clinical outcomes in ToF patients.
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