Evidence map›Paper›PMID 42131079›Full record

ArticleACS catalysis2026

Biosynthesis of 6-thioguanine: characterizing two intermediates involved in its thioamide formation reaction.

Kelin Li, Juan Lopez, Zion Kang, Ziwei Wang, Sha Hu, Tao Zhang, Xufeng Fang, Blair Szymczyna, Mark W Grinstaff, Pinghua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelin LiDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Juan LopezDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Zion KangDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Ziwei WangDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Sha HuDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Tao ZhangDepartment of Chemistry, Boston University, Boston, MA, USA.
Xufeng FangDepartment of Chemistry, Boston University, Boston, MA 02215 USA.
Blair SzymczynaDepartment of Chemistry, Boston University, Boston, MA, USA.
Mark W GrinstaffDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Pinghua LiuDepartment of Chemistry, Boston University, Boston, MA 02215, USA.

Funding

Alkaloid Biosynthetic StudiesR01GM140040 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LIU, PINGHUA · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM140040
6 · The paper itself

Abstract

6-Thioguanosine 5'-monophosphate (6-TGMP) is the biologically active nucleotide form of the antimetabolite 6-thioguanine produced by

Indexed as

adenylation intermediateC-S lyasesulfur-containing natural productsthioamidationthioguanine biosynthesis

Identifiers

PMID42131079
PMCPMC13166134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.