Evidence map›Paper›PMID 42130947›Full record

ArticlePatterns (New York, N.Y.)2026

Helix 1.0: An open-source framework for reproducible and interpretable machine learning on tabular scientific data.

Eduardo Aguilar-Bejarano, Daniel Lea, Karthikeyan Sivakumar, Jimiama M Mase, Reza Omidvar, Ruizhe Li, Troy Kettle, James Mitchell-White, Morgan R Alexander, David A Winkler and 1 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eduardo Aguilar-BejaranoDigital Research Service, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK.
Daniel LeaDigital Research Service, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK.
Karthikeyan SivakumarDigital Research Service, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK.
Jimiama M MaseDigital Research Service, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK.
Reza OmidvarDigital Research Service, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK.
Ruizhe LiSchool of Computer Science, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, UK.
Troy KettleSchool of Computer Science, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, UK.
James Mitchell-WhiteDigital Research Service, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK.
Morgan R AlexanderSchool of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
David A WinklerDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC 3086, Australia.
Grazziela FigueredoHealth Informatics, School of Medicine, University of Nottingham, Medical School, Nottingham NG7 2UH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helix is an open-source, extensible, Python-based software framework to facilitate reproducible and interpretable machine learning workflows for tabular data. It addresses the growing need for transparent experimental data analytics provenance, ensuring that the entire analytical process-including decisions around data transformation and methodological choices-is documented, accessible, reproducible, and comprehensible to relevant stakeholders. The platform comprises modules for standardized data preprocessing, visualization, machine learning model training, evaluation, interpretation, results inspection, and model prediction for unseen data. To further empower researchers without formal training in data science to derive meaningful and actionable insights, Helix features a user-friendly interface that enables the design of computational experiments and inspection of outcomes, including a novel interpretation approach to machine learning decisions using linguistic terms all within an integrated environment.

Indexed as

data provenanceFAIRhealthcare data modelingmachine learningmachine learning interpretabilityQSAR modelingQSPR modelingreproducibility

Identifiers

PMID42130947
PMCPMC13161695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.