ArticleTherapeutic advances in musculoskeletal disease2026
Long-term dynamic of muscle mass and its effectors in female patients with rheumatoid arthritis: a 5-year prospective cohort study.
Article in Therapeutic advances in musculoskeletal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Rheumatoid arthritis (RA) patients with low muscle mass (myopenia) have a higher risk of physical dysfunction and poor prognosis. However, the evidence of longitudinal changes in muscle mass in female RA patients was scarce. Objectives: This study aimed to explore the long-term muscle dynamics and their potential effectors in female RA patients. Design: A 5-year prospective cohort study. Methods: Female RA patients without a diagnosis of myopenia at baseline were included if they finished the time frame of 5-year follow-up and had at least 2 times of muscle assessments by bioelectric impedance analysis. Linear mixed-effect models (LMEM) were used to analyze the annual progression rates of the appendicular skeletal muscle index (ASMI). Results: There were 210 female RA patients included, with a mean age of 48.4 ± 10.9 years and a median disease duration of 48 (interquartile range (IQR) 19, 95) months. During the median follow-up time of 4.73 (IQR: 2.86-5.15) years, the multivariable-adjusted annual decline rate of ASMI was -0.021 (standard error (SE) 0.007) (95% CI: -0.034 to -0.007, Conclusion: Our findings firstly illustrated the annual decline rate of muscle mass in female RA patients from a 5-year longitudinal data, and revealed the potential effect of tight control of disease activity and less glucocorticoid use for delaying the loss of muscle mass.
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