ArticleFrontiers in public health2026
Twelve-year trends in cervical cytology screening: a retrospective analysis of 83,148 smears from a Turkish tertiary care center.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Epidemiology of Human Papillomavirus in the Middle East and North Africa: A Review of Genotypic Prevalence, Vaccination Challenges, and Non-Cervical Clinical Outcomes.Diseases (Basel, Switzerland) · 2026Review
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6 authors.
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Abstract
Introduction: Cervical cancer screening through cytology and human papillomavirus (HPV) testing is essential for early detection of precancerous lesions, yet long-term institutional data integrating cytological trends, HPV genotype epidemiology, and diagnostic performance from Turkey remain limited. This study aimed to analyze the distribution and temporal trends of cervical cytological abnormalities, HPV prevalence and genotype distribution, and cytology-histopathology concordance over a 12-year period at a tertiary care center in Istanbul. Methods: A retrospective analysis of all cervical smear samples collected between January 2014 and December 2025 was conducted. Cytology results were classified according to the Bethesda 2014 system. HPV testing, which was performed on a subset of the study population based on clinical indications and kit availability, included mRNA-based assay (Aptima, 2020-2021, Results: Among 83,148 cervical smear records, 76,232 evaluable results from women aged ≥21 years were included. The overall epithelial cell abnormality rate was 7.93%, with atypical squamous cells of undetermined significance (5.83%) and low-grade squamous intraepithelial lesions (1.77%) being the most common findings. Epithelial cell abnormality rates varied significantly across age groups, with the highest rate in the 18-20 age group (12.78%) and a significant inverse correlation with increasing age ( Conclusion: The 12-year analysis shows a decrease in cervical cytological abnormalities and provides valuable epidemiological data on HPV genotype distribution in a Turkish population. The high prevalence of non-vaccine-targeted genotypes, such as HPV-56 and HPV-51, should be considered in future vaccination strategies.
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