Evidence map›Paper›PMID 42130850›Full record

ArticleRSC advances2026

pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes.

Yaling Wu, Peipei Xu, Jing Lin, WanJing Li, Qing Lin, Hanhao Lu, Jingbo Chen, Zhenhua Liu, Yudong Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaling WuSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University Fu-zhou Fujian 350108 China 2934@mju.edu.cn.
Peipei XuSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University Fu-zhou Fujian 350108 China 2934@mju.edu.cn.ORCID https://orcid.org/0009-0007-0968-0574
Jing LinSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University Fu-zhou Fujian 350108 China 2934@mju.edu.cn.
WanJing LiSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University Fu-zhou Fujian 350108 China 2934@mju.edu.cn.
Qing LinSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University Fu-zhou Fujian 350108 China 2934@mju.edu.cn.
Hanhao LuDepartment of Oncology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital Fuzhou 350001 China cjbfjsl@fjmu.edu.cn liuzhenhua6909@163.com.
Jingbo ChenDepartment of Oncology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital Fuzhou 350001 China cjbfjsl@fjmu.edu.cn liuzhenhua6909@163.com.
Zhenhua LiuDepartment of Oncology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital Fuzhou 350001 China cjbfjsl@fjmu.edu.cn liuzhenhua6909@163.com.
Yudong LuCollege of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Oriented Chemical Engineer, Fujian Key Laboratory of Polymer Materials, Fujian Normal University Fuzhou Fujian 350117 China luyd@fjnu.edu.cn (+86) 156-5916-8406.ORCID https://orcid.org/0000-0002-8060-2671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer chemotherapy often faces challenges such as rapid drug clearance, non-specific biodistribution, and burst release, leading to systemic toxicity and reduced therapeutic efficacy. To overcome these limitations, this study developed a colon-targeted sustained-release hydrogel bead system based on β-cyclodextrin (β-CD) and biocompatible polymers (CMCS/CMCNa/SA). The results demonstrated that the incorporation of β-CD significantly enhanced the drug loading capacity through host-guest interactions. Under the optimal mass ratio of drug complex to wall material (15 : 35), the encapsulation efficiency reached as high as 81.23%. Drug release kinetics showed high correlation coefficients (

Identifiers

PMID42130850
PMCPMC13165014

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.