ArticleFrontiers in aging neuroscience2026
Evaluation of conductivity tensor image along the perivascular space in the brains of patients with cognitive impairments.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index has been proposed as an imaging marker of impaired perivascular water transport across the Alzheimer's disease (AD) continuum. Whether a conductivity-based ALPS derived from conductivity tensor imaging (CTI) provides a distinct physiological perspective remains to be explored. This work introduces the CTI-ALPS index. The purpose of this study was (1) to introduce the CTI-ALPS index and (2) to evaluate both the CTI-ALPS and DTI-ALPS indices in cognitively normal (CN) older adults, amnestic mild cognitive impairment (aMCI), and mild-to-moderate AD. Methods: In this prospective cross-sectional study, 110 participants (CN, Results: CTI-ALPS showed lower in AD but did not differ significantly across groups and demonstrated weaker associations with Mini-Mental State Examination (MMSE) scores. In age-adjusted ROC analyses for differentiating AD from CN, CTI-ALPS achieved modest discrimination, whereas DTI-ALPS provided slightly higher diagnostic performance. Conclusion: CTI-ALPS demonstrated a non-significant trend towards a reduction in AD and modest diagnostic utility, with weaker clinical associations than DTI-ALPS in this cohort. As an initial exploratory study, conductivity-based ALPS may serve as a distinct physical contrast reflecting ionic physiological perivascular marker, alongside diffusion-based measures, and warrants further validation with larger, age-matched datasets and reproducibility-focused designs.
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