ArticleFrontiers in endocrinology2026
Comparative efficacy of modified antagonist protocols combining clomiphene citrate or letrozole for ovarian stimulation in patients with normal ovarian reserve.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: To compare the efficacy of modified gonadotropin-releasing hormone (GnRH) antagonist protocols combining clomiphene citrate (CC) or letrozole (LE) versus a conventional antagonist protocol in patients with normal ovarian reserve, aiming to reduce gonadotropin (Gn) consumption and ovarian hyperstimulation syndrome (OHSS) risk. Methods: This retrospective cohort study included 565 Results: Baseline characteristics were similar among groups. Both CC and LE groups required significantly shorter Gn duration and lower total Gn dose than the control group (both Conclusions: Modified GnRH antagonist protocols with CC or LE were associated with reduced Gn and antagonist consumption and decrease oocyte yield but were associated with higher embryo quality metrics and achieve comparable clinical pregnancy outcomes in normal ovarian reserve patients. These protocols are associated with reduced medication costs to conventional stimulation.
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