Characterization of elevated levels of endometrial renin-angiotensin system components suggest a role in endometrial repair.

Tess L Symington, Joshua J Fisher, Wei Zhou, Evdokia Dimitriadis, Eugenie R Lumbers, Paul Tooney, Kirsty G Pringle

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Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Tess L SymingtonSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.

Joshua J FisherReproductive and Family Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.

Wei ZhouDepartment of Obstetrics and Gynecology, University of Melbourne, Parkville, VIC, Australia.

Evdokia DimitriadisDepartment of Obstetrics and Gynecology, University of Melbourne, Parkville, VIC, Australia.

Eugenie R LumbersSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.

Paul TooneySchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.

Kirsty G PringleSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Each month, the endometrium is shed, regenerated, and transformed in response to changing hormone levels. These processes occur in a tightly regulated manner, and irregularities are linked with reproductive health conditions such as endometriosis and infertility. The renin-angiotensin system is known to be under hormonal control and to drive proliferation and differentiation in tissues, but its expression across the endometrial cycle is not well characterized. Therefore, this study aimed to describe the spatial-temporal localization and gene expression of key initiators of renin-angiotensin system signaling, prorenin, the prorenin receptor, and angiotensinogen, across the endometrial cycle. Methods: Endometrial tissue was collected from participants within the proliferative phase, mid-secretory phase, and late-secretory phase of their endometrial cycle (n=10/phase). Prorenin ( Results: Both prorenin ( Conclusion:

Indexed as

EndometriumRenin-Angiotensin SystemAdultAngiotensinogenFemaleHumansMenstrual CycleProrenin ReceptorReceptors, Cell SurfaceReninRNA, MessengerVacuolar Proton-Translocating ATPasesAngiotensinogenATP6AP2 protein, humanProrenin ReceptorReceptors, Cell SurfaceReninRNA, MessengerVacuolar Proton-Translocating ATPasesangiotensinogenendometrial cycleendometriumproreninprorenin receptorrenin-angiotensin system

Identifiers

PMID42130729

DOI10.3389/fendo.2026.1817846

PMCPMC13160814

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