ArticleACS pharmacology & translational science2026
Synthesis, Biological Evaluation, and Computational Study of Pyridine- and Indazole-Based Inhibitors of the Inducible Nitric Oxide Synthase as Promising Antipsoriatic Agents.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The dysregulation of inducible nitric oxide synthase (iNOS) is linked to various diseases, including psoriasis, where it contributes to imbalanced nitro-oxidative stress. iNOS is primarily produced in the skin's epidermal layer and can be activated by cytokines elevated in psoriatic lesions, such as TNF-α and IL-17. Macrophages also play a role in psoriasis by producing cytokines and iNOS, and patients show increased levels of these immune cells in lesions. Given the association of iNOS with psoriasis severity, it is seen as a potential therapeutic target. However, no specific iNOS inhibitor has been reported as a treatment for psoriasis. The study describes the synthesis of new compounds based on prior iNOS inhibitors, their potency and selectivity of action, and the evaluation of the most interesting compounds in different
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