Evidence map›Paper›PMID 42130684›Full record

ArticleMaterials letters2025

Rational hydrogel design to improve brain modulus matching for implantation.

Molli Garifo, Keturah Bethel, Eric M Davis, Jessica Larsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Molli GarifoDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.ORCID 0000-0003-0414-3108
Keturah BethelDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.ORCID 0000-0002-1463-5918
Eric M DavisDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.
Jessica LarsenDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.ORCID 0000-0003-2756-9523

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Transnational Research Imaging Core (TRI)P30GM131959 · NIGMS · CLEMSON UNIVERSITY · PI VYAVAHARE, NAREN R · 2019 to 2023
$5.9M
NIGMS NIH HHS P20 GM103499NIGMS NIH HHS P30 GM131959
6 · The paper itself

Abstract

Treating the brain is challenging due to the restrictive blood-brain barrier, and modulus-mismatched implants often cause problems. Herein, we have fabricated copolymer hydrogels from thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), -r-hydrophilic polymer, poly(acrylic acid) (PAA), which are injectable and transform into soft implants above their lower critical solution temperature (LCST). PAA concentration can be leveraged to tune the LCST and viscosity of the PNIPAAm-

Indexed as

HydrogelNeural biomaterialsPoly(acrylic acid)Poly(N-isopropylacrylamide)

Identifiers

PMID42130684
PMCPMC13166124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.