ArticleFrontiers in oncology2026
Vertebral involvement in Erdheim-Chester disease: a case report of non-BRAF-driven diagnosis and treatment challenges.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that is frequently misdiagnosed because of its nonspecific systemic symptoms. We report the case of a 73-year-old woman who presented with persistent back pain, abdominal discomfort, and fever. Imaging revealed predominant thoracolumbar vertebral involvement, characterized by multifocal osteosclerosis on computed tomography and abnormal signal intensity with contrast enhancement on magnetic resonance imaging. This radiologic pattern may closely mimic inflammatory disorders, hematologic malignancies, or metastatic disease. Vertebral biopsy established the diagnosis of ECD. Molecular analysis of peripheral blood did not identify actionable driver mutations in the MAPK/PI3K signaling pathways, including
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