Ruptured sinus of Valsalva aneurysm with associated ventricular septal defect: a case report.

Introduction and importance: Sinus of Valsalva aneurysm (SOVA) is a rare cardiac anomaly, occurring in approximately 0.09% of the population and accounting for 0.1-3.5% of congenital heart defects. It represents a dilation between the aortic annulus and the sinotubular ridge. Rupture occurs in nearly 35% of cases, most commonly from the right coronary sinus into the right heart chambers, and may precipitate acute left-to-right shunting, heart failure, or sudden death. Ventricular septal defects (VSDs) coexist in 30-50% of SOVA cases, further increasing structural and hemodynamic complexity. Case presentation: We report a 64-year-old woman with no prior cardiac diagnosis who presented with acute dyspnea and a 2-year history of exertional breathlessness. Clinical evaluation revealed a systolic murmur, dilated left ventricle (LVEDD: 59 mm), severe left atrial enlargement (volume index: 61 ml/m Clinical discussion: This case highlights the diagnostic and therapeutic challenges of ruptured SOVA with concurrent VSD, especially in older patients. The coexistence of lesions exacerbates shunting and accelerates decompensation. Echocardiography with Doppler flow is crucial for diagnosis. Surgical repair remains the definitive treatment, providing excellent prognosis when performed promptly. The case also underscores the embryological link between membranous VSD and right SOVA, with a higher incidence of right-sided ruptures into the RV observed in Asian populations. Timely recognition, surgical expertise, and valve-preserving techniques are essential for favorable outcomes. Conclusion: Ruptured SOVA with concurrent VSD is a rare but life-threatening anomaly. Early diagnosis and prompt surgical intervention are critical to optimize survival and preserve cardiac function.