Evidence map›Paper›PMID 42130469›Full record

ArticleJournal of clinical pharmacology2026

A Phase 1 Oral Mass Balance and Combined Intravenous [

Shriram M Pathak, Nozomi Hayata, Takashi Ueno, Jagadeesh Aluri, Jincao Wu, Ashley S Brooks, Catherine M Laing, Lea Dutta, Sanae Yasuda

Abstract readClinical Trial, Phase I
In one paragraph

Article in Journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shriram M PathakClinical Pharmacology Science, Eisai Ltd., UK.
Nozomi HayataDeep Human Biology Learning, Eisai Co., Ltd, Japan.
Takashi UenoGlobal Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd, Japan.
Jagadeesh AluriClinical Pharmacology Science, Eisai Inc., USA.
Jincao WuBiostatistics, Eisai Inc., USA.
Ashley S BrooksEarly Phase Research, MAC Clinical Research, UK.
Catherine M LaingFortrea Clinical Research Unit Ltd., UK.
Lea DuttaOncology Clinical Research, Eisai Inc., USA.
Sanae YasudaDeep Human Biology Learning, Eisai Co., Ltd, Japan.

Funding

Eisai Ltd.
6 · The paper itself

Abstract

E7386, an orally active protein-protein interaction inhibitor, is reported to impair the interaction between transcriptional co-activator CREB-binding protein and β-catenin. A competent study design exploring the concomitant dosing routes, sensitive intravenous (IV; [

Indexed as

Antineoplastic AgentsAdministration, IntravenousAdministration, OralAdultBiological AvailabilityCarbon RadioisotopesFecesHumansMaleMiddle AgedAntineoplastic AgentsCarbon Radioisotopesclinical pharmacologyIV 14C microtracermass balancePBPKradiolabeled

Identifiers

PMID42130469
PMCPMC13173392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.