ArticleBioanalysis2026
Comparison of 2D-LC and LC-MS/MS self- calibration internal standard method for the determination of quetiapine in serum.
Article in Bioanalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objective2D-LC method and LC-MS/MS self-calibrated internal standard method were used to compared the consistency and correlation of quetiapineserum concentration.
methodsQuality control samples at low, medium, and high concentrations of quetiapine, as well as serum samples from 138 psychiatric patients taking quetiapine, were analyzed using 2D-LC and LC-MS/MS self-calibrated internal standard method, respectively. Performed a complete validation of both methods. The Bland-Altman plot was used to assess the consistency of the results, while Pearson correlation analysis and Passing-Bablok regression were used to analyze the correlation among the results. OUTCOMES: The linear range for 2D-LC was 60.74-1518.48 ng/ml, and the linear range for LC-MS/MS self-calibrated internal standard method was 60.88-1522.02 ng/ml. For both methods, the relative standard deviation of intraday and daily precision was less than 15%. Calculated using the Bland-Altman plot, the 95.65% LoA was (-11.85, 30.82). The Passing-Bablok regression equation was OLZ
conclusionThe 2D-LC and LC-MS/MS self-calibrated internal standard method, exhibit exceptional agreement and correlation in the quantification of quetiapine concentrations in serum. which can be used for conventional therapeutic drug monitoring (TDM).
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