ArticlePest management science2026
Coordinated sequestration and transcriptional regulation drive CSP2-mediated chlorpyrifos resistance in Nilaparvata lugens.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInsecticide resistance in the brown planthopper, Nilaparvata lugens, poses a major threat to rice production. Beyond metabolic detoxification, sequestration by chemosensory proteins (CSPs) has emerged as a vital resistance mechanism. Our earlier work identified CSP2 as a contributor to chlorpyrifos resistance. However, the molecular basis of its insecticide binding and the transcriptional regulation governing its overexpression remained elusive.
resultsThis study demonstrates that CSP2 confers resistance by functioning as a broad-spectrum scavenger, binding with high affinity to both chlorpyrifos (inhibition constant, K
conclusionOur findings reveal a sophisticated, multi-layered resistance strategy in N. lugens. CSP2 provides a frontline, sequestration-based defense that complements the previously characterized CYP6BD12-inhibition mechanism of CSP15. The functional differentiation between these CSPs, coupled with the novel FoxO-mediated regulatory pathway for CSP2, illustrates a complex adaptive network. © 2026 Society of Chemical Industry.
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