ArticleThe Journal of international medical research2026
Role of disturbed structural connectivity network in patients with white matter lesions and cognitive impairment revealed by diffusion-tensor magnetic resonance imaging.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveThis study aimed to compare small-world network attributes between control participants without memory complaints and patients with white matter lesions showing cognitive impairment.MethodsChanges in diffusion tensor imaging and white matter fiber bundles in patients were analyzed. Brain structural network was constructed based on diffusion tensor imaging data, and topological properties of whole-brain small-world network were discussed. The damaged brain areas of patients with white matter lesions were studied, and the correlation between white matter lesion-related brain structural network abnormalities and cognitive impairment severity was discussed.ResultsCompared with the normal control with normal cognition group, fractional anisotropy was significantly reduced in the white matter lesions-non-dementia vascular cognitive impairment (WMLs-VCIND) and white matter lesions-vascular dementia (WMLs-VaD) groups, while mean diffusivity and radial diffusivity values were significantly increased (
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