ArticleActa obstetricia et gynecologica Scandinavica2026
The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt-1 in women with new onset hypertension in pregnancy.
Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionTo assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control (<135/85 mmHg). MATERIAL AND
methodsThis was a prospective study that assessed women at presentation with hypertension and after 1 and 2 weeks of antihypertensive therapy. At each visit, blood pressure (BP) and blood tests to obtain levels of sFlt-1 and PLGF were taken. A multilevel linear mixed-effects model was performed to compare the repeated measurements of sFlt-1 and PLGF, controlling for maternal demographics, diagnosis at presentation, and antihypertensive agent used. The cohort was further subdivided into two groups based on how quickly they achieved target BP control to assess whether the degree of initial control influenced the angiogenic profile. Group 1 achieved BP < 135/85 after 1 week, while group 2 after 2 weeks of treatment.
resultsA total of 133 women were recruited into the study, 47 in group 1 and 86 in group 2. For the total cohort, both systolic blood pressure (SBP) and diastolic blood pressure (DBP) dropped after 1 week on antihypertensive medication (p < 0.001) and remained stable thereafter. Log
conclusionsIn pregnant women with new-onset hypertension, tight BP control leads to a reduction in SBP and DBP within the first week of antihypertensive treatment. Log
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.