ReviewNucleic acids research2026
Signal or noise? RNA-binding proteins and the challenges of binding site assignments.
Review in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- OTTR-CLASH: improved biochemical and bioinformatic identification of Argonaute 2-mediated microRNA-target RNA interactions.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A significant body of research has been devoted to pinpointing and cataloguing the binding sites of RNA-binding proteins (RBPs) on target transcripts. The most common techniques involve crosslinking and immunoprecipitation (CLIP) followed by high-throughput sequencing. In this review, we provide a comprehensive summary of the major advancements in CLIP-based techniques and state-of-the-art data analysis methods designed for identifying and analysing the binding sites of RBPs. We also brief on methods used to determine the functional relevance of these binding sites and, in addition, delve into the major hurdles faced in the detection and elucidation of the binding sites of RBPs. Finally, we explore reproducibility concerns in the CLIP field, and conclude by suggesting potential avenues for future improvements.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.