Evidence map›Paper›PMID 42130011›Full record

ArticleChemistry & biodiversity2026

Cytotoxic Profiling of 3',4',5'-Trimethoxychalcones Reveals Cell-Line-Dependent Cytotoxic Activity: An In Vitro and In Silico Study.

Aleksandar Y Mehandzhiyski, Abdessamad Beraich, Zhivko Velkov, Maya Zaharieva, Spiro Konstantinov, Daniela Batovska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleksandar Y MehandzhiyskiLaboratory of Organic Electronics, Department of Science and Technology (ITN), Linköping University, Norrköping, Sweden.
Abdessamad BeraichPhysical Chemistry of the Natural Resources and Processes, Department of Chemistry, Faculty of Sciences, Mohamed First University, Oujda, Morocco.
Zhivko VelkovDepartment of Chemistry, South-West University "Neofit Rilski", Blagoevgrad, Bulgaria.
Maya ZaharievaDepartment of Infectious Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Spiro KonstantinovDepartment of Pharmacology, Pharmacotherapy and Toxicology, Medical University of Sofia, Faculty of Pharmacy, Sofia, Bulgaria.
Daniela BatovskaInstitute of Chemical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic activity of a series of 3',4',5'-trimethoxychalcones (1-25) was evaluated against multiple human cancer cell lines under uniform experimental conditions. The compounds were designed to bear simple substitutions on ring B to allow direct comparison of substitution effects. Most derivatives showed higher cytotoxic potency than the reference drug melphalan in the more responsive models. Several compounds exhibited submicromolar half-maximal inhibitory concentration (IC

Indexed as

Antineoplastic AgentsChalconesCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsChalconescell line–dependent activitychalconescytotoxicitymolecular docking

Identifiers

PMID42130011
PMCPMC13172435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.