Evidence map›Paper›PMID 42129901›Full record

ArticleJournal of anesthesia, analgesia and critical care2026

Indications, therapeutic modalities and clinical outcomes of hyperbaric oxygen therapy in Italy, the ITA-OTI Study: a multicentre prospective observational study.

Mariachiara Ippolito, Luca Martani, Alberto Noto, Laura Maniscalco, Giulia Spurio, Marina Nasello, Salvatore Sardo, Vincenzo Francesco Tripodi, Savino Borraccino, Luigi Giancarlo Vicari Sottosanti and 13 more

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In one paragraph

Article in Journal of anesthesia, analgesia and critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mariachiara IppolitoDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C), University of Palermo, Palermo, 90127, Italy. mariachiara.ippolito@unipa.it.
Luca MartaniAnesthesiology, Critical Care and Hyperbaric Medicine Unit, Vaio Hospital, AUSL Parma, Fidenza, Italy.
Alberto NotoDivision of Anesthesia and Intensive Care, Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Policlinico "G. Martino," University of Messina, Messina, Italy.
Laura ManiscalcoDivision of Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities, University of Palermo, Palermo, Italy.
Giulia SpurioDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C), University of Palermo, Palermo, 90127, Italy.
Marina NaselloDepartment of Anaesthesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, Via del Vespro 129, Palermo, 90127, Italy.
Salvatore SardoDepartment of Medical Sciences and Public Health, University of Cagliari, Monserrato, 09042, Italy.
Vincenzo Francesco TripodiDivision of Anesthesia and Intensive Care, Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Policlinico "G. Martino," University of Messina, Messina, Italy.
Savino BorraccinoAnesthesia and Intensive Care Complex Unit, Cannizzaro Emergency Hospital, Catania, Italy.
Luigi Giancarlo Vicari SottosantiAnesthesia and Intensive Care Complex Unit, Cannizzaro Emergency Hospital, Catania, Italy.
Carlotta FerraroAnesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Viale Gramsci 14, Parma, 43126, Italy.
Luca CantadoriAnesthesiology, Critical Care and Hyperbaric Medicine Unit, Vaio Hospital, AUSL Parma, Fidenza, Italy.
Andrea Neville CracchioloUnit of 118 Emergency Medical Services and Hyperbaric Medicine, ARNAS Civico Di Cristina Benfratelli Hospital, Palermo, Sicily, Italy.
Luigi TargaDomus Medica Private Clinic, San Marino, Republic of San Marino.
Fiorenzo FracassoTaranto Military Hospital - Hyperbaric Medicine Service, Taranto, Italy.
Andrea GiovanielloHyperbaric Oxygen Therapy Unit, Habilita - Casa Di Cura I Cedri, Fara Novarese, Italy.
Fiammetta RongaDepartment of Anaesthesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, Via del Vespro 129, Palermo, 90127, Italy.
Claudio SpenaEmergency Department, SSD Emergency Plans Management - ATS Liguria - ASL2, San Paolo Hospital, Savona, Italy.
Elena Giovanna BignamiAnesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Viale Gramsci 14, Parma, 43126, Italy.
Domenica MatrangaDivision of Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities, University of Palermo, Palermo, Italy.
Antonino GiarratanoDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C), University of Palermo, Palermo, 90127, Italy.
Andrea CortegianiDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C), University of Palermo, Palermo, 90127, Italy.
SIAARTI Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReal-world data describing contemporary hyperbaric oxygen therapy (HBOT) practice in Italy are limited. This study aimed to describe current clinical indications and therapeutic modalities of HBOT at the national level.

methodsWe conducted a multicentre, prospective, observational national study, promoted by Italian Society of Anesthesia Analgesia, Resuscitation and Intensive Care (SIAARTI). We included consecutive patients who underwent HBOT in 10 study centres within a period of 12 weeks, for any treatment indication. The primary outcome of the study was the proportion of treatments by clinical indication and urgency of treatment.

resultsOverall, 327 patients were included across 10 centres, of which 73.7% (n = 241) received elective and 26.3% (n = 86) urgent treatments. The most frequent indication was sudden hearing loss (35.8%), followed by carbon monoxide poisoning (19.9%) and soft tissue infection (12.2%). Treatments were delivered at a median of 2.5 ATA, with two oxygen cycles for session and a median of 16 sessions for patients. No serious adverse events occurred.

conclusionsIn Italy, HBOT is applied in accordance with national and international guidelines. The most frequent indications to treatment were sudden hearing loss, carbon monoxide poisoning, and soft tissue infections. Treatments had similar characteristics across the centres, with heterogeneity mainly regarding the number of sessions per patient. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Hyperbaric oxygen therapyItalyObservationalProspective

Identifiers

PMID42129901
PMCPMC13340085

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.