ArticleMicrobiome2026
Bifidobacterium-driven immunoglobulin A production in pediatric patients with IgA deficiency and recurrent respiratory tract infections.
Article in Microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
backgroundImmunoglobulin A (IgA) deficiency is the most common primary antibody deficiency and contributes to recurrent respiratory tract infections (rRTIs) in children, with prevalence rates in this group ranging from 1:4 to 1:65. Previous studies in healthy humans and animals suggest that the gut microbiota significantly influences IgA production. We investigated the role of the gut microbiota in IgA deficiency and its potential in promoting IgA induction in children with rRTIs.
resultsChildren under 7 years of age with rRTIs were enrolled in a prospective cohort study. Serum and feces were collected for IgA level measurement using ELISA and to determine the composition of the intestinal microbiota by 16S rRNA sequencing. We included 82 children with rRTIs, 38% of whom were IgA deficient. The microbiota composition of IgA deficient children differed from that of symptomatic non-IgA deficient children (PERMANOVA R
conclusionsThis study shows that children with IgA deficiency and rRTIs harbour a distinctly altered intestinal microbiota. Using fecal transfers from pediatric donors into germ-free mice, we demonstrate robust induction of IgA across mucosal sites. Notably, a Bifidobacterium-dominated community cluster was linked to stronger IgA responses in stool, serum, and lung, highlighting a microbiota-mucosal immunity axis with translational potential. Video Abstract.
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