SynthesisBMC cancer2026
Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies.
Synthesis in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeThis study aimed to systematically evaluate the associations between oral health conditions, including periodontitis, tooth loss, and dental caries, and colorectal cancer (CRC) risk. MATERIALS AND
methodsPubMed, Embase, the Cochrane Library, Web of Science, Scopus, and Google Scholar were searched from inception to January 12, 2026 for observational studies assessing oral health conditions in relation to CRC risk. Adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled for the primary meta-analysis. Subgroup analyses were conducted according to sex, smoking status, diagnostic method, tumor location, geographic region, and adjustment quality to explore potential sources of heterogeneity. Sensitivity analyses included leave-one-out analysis to assess the robustness of the findings. A dose-response analysis was performed to evaluate the association between the number of missing teeth and CRC risk. Study quality was assessed using the Newcastle-Ottawa Scale (NOS).
resultA total of 15 studies were included. Periodontitis was associated with an increased risk of CRC (HR = 1.24, 95% CI: 1.04-1.48; I
conclusionPeriodontitis is associated with an increased risk of CRC, whereas current evidence does not support significant associations for tooth loss or dental caries. Given the observational nature of the included studies and the presence of heterogeneity, these findings should be interpreted with caution. Further well-designed prospective cohort studies are warranted to clarify the relationship between oral health and CRC risk.
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