Observational studyBMC gastroenterology2026
A prospective cohort-based prediction model incorporating acute gastrointestinal injury for 28-day and 90-day outcomes in acute decompensation of cirrhosis.
Observational study in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
BACKGROUND AND
aimsThis prospective, observational study evaluated the role of acute gastrointestinal injury (AGI) in the 28-day and 90-day prognosis of cirrhotic patients with acute decompensation (AD).
methodsThe baseline clinical characteristics of AD patients (N = 231) were recorded, and gastrointestinal function (GIF) was assessed. The patients were divided into three AGI groups based on their AGI grade (according to the European Society of Intensive Care Medicine guidelines), and they were followed for 90 days or until either death or liver transplantation.
resultsDuring the 90-day follow-up period, 63 patients (22.27%) died and 2 (0.87%) underwent liver transplantation. Cox regression analyses identified endotoxin, creatinine, international normalized ratio (INR), infection status, and the occurrence of AGI as independent predictors of 28-day and 90-day death or transplantation. These five predictors were entered into the final Cox regression model to construct predictive models for 28-day (AGIM28) and 90-day (AGIM90) outcomes. Corresponding nomograms were subsequently developed. Of six prognostic models, the AGIM models had the highest prediction efficiency. In the Kaplan-Meier survival curve analysis, the 90-day cumulative survival rate of the three AGI groups (no-AGI, AGI 1, and AGI 2) decreased gradually (P < 0.001). Multivariate logistic analysis showed that d-lactate, bilirubin, INR, and bowel sounds were independent predictors of AGI progression.
conclusionOur novel prediction models, the AGIM28 and AGIM90, can effectively predict the 28-day and 90-day death or transplantation risk of cirrhotic patients with AD. The presence of AGI plays an undeniable role in the poor prognosis of AD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.