Evidence map›Paper›PMID 42129633›Full record

ArticleThe journal of headache and pain2026

A neural substrate for targeted analgesia associated with attenuated serotonergic transmission in a mouse model of medication overuse headache.

Deqi Zhai, Chunxiao Yang, Zihua Gong, Yingyuan Liu, Yu Wang, Huijuan Yuan, Weinan Na, Huanxian Liu, Shuqing Wang, Longteng Ma and 2 more

Abstract read
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In one paragraph

Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Deqi ZhaiDepartment of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.ORCID http://orcid.org/0009-0004-2636-8417
Chunxiao YangDepartment of Neurology, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Zihua GongDepartment of Neurology, Bethune International Peace Hospital, Shijiazhuang, Hebei, China.
Yingyuan LiuDepartment of Neurology, Peking Union Medical College Hospital, Beijing, China.
Yu WangSchool of Basic Medical Sciences, Tsinghua University, Beijing, China.
Huijuan YuanDepartment of Neurology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Weinan NaDepartment of Neurology, School of Medicine, Nankai University, Tianjin, China.
Huanxian LiuDepartment of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Shuqing WangDepartment of Neurology, Beijing Electric Power Hospital, Beijing, China.
Longteng MaDepartment of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Shengyuan YuDepartment of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Zhao DongDepartment of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, China. dong_zhaozhao@126.com.ORCID http://orcid.org/0000-0002-4581-2569

Funding

the National Key R&D Program of China 2023YFC2508701the National Natural Science Foundation of China 82171208
6 · The paper itself

Abstract

backgroundMedication overuse headache (MOH) is a chronic disorder due to excessive acute headache treatment use. Neuroimaging studies suggest the involvement of the orbitofrontal cortex (OFC) in the pathophysiology of MOH, particularly its connections with the periaqueductal gray (PAG). The OFC-vlPAG circuit has been well-established as a critical neural substrate in pain regulation; while its role in triptan-related MOH pathogenesis remains unclear. This study aims to investigate the role of the OFC-vlPAG circuit and its underlying mechanisms in regulating mechanical hypersensitivity using a triptan-induced MOH mouse model.

methodsMale C57BL/6J mice (along with a female exploratory cohort) were used to develop a triptan-induced MOH model through repeated rizatriptan (RIZ) administration. Behavioral assessments of cutaneous allodynia were conducted using von Frey filaments. Immunofluorescence staining was performed to examine neuronal activity and 5-HT

resultsRepeated RIZ administration induced cutaneous allodynia in the MOH mouse model, with significant reductions in hind paw and head withdrawal thresholds. Elevated c-Fos expression in the vlOFC CaMKII-α

conclusionsActivating the glutamatergic OFC-vlPAG circuit elicits robust analgesia in triptan-induced MOH mice. 5-HT CLINICAL TRAIL NUMBER: Not applicable.

Indexed as

Headache Disorders, SecondaryPeriaqueductal GrayPrefrontal CortexReceptor, Serotonin, 5-HT1DAnimalsDisease Models, AnimalFemaleHyperalgesiaMaleMiceMice, Inbred C57BLTriazolesTryptaminesReceptor, Serotonin, 5-HT1DrizatriptanTriazolesTryptamines5-HT1D receptorsChemogeneticsGlutamatergic neuronsMedication overuse headacheOrbitofrontal cortexPain modulationPeriaqueductal gray

Identifiers

PMID42129633
PMCPMC13339282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.