Evidence map›Paper›PMID 42129569›Full record

ArticleNature2026

Subspace communication in the hippocampal-retrosplenial axis.

Joaquin Gonzalez, Mihály Vöröslakos, Deren Aykan, Nina Soto, Noam Nitzan, Rachel Swanson, Mursel Karadas, Zhe Sage Chen, György Buzsáki

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joaquin Gonzalez *Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Mihály Vöröslakos *Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1022-1355
Deren AykanNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.
Nina SotoNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.
Noam NitzanNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.
Rachel SwansonNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.
Mursel KaradasNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3685-576X
Zhe Sage ChenDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA. zhe.chen@nyulangone.org.ORCID http://orcid.org/0000-0002-6483-6056
György BuzsákiNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA. gyorgy.buzsaki@nyulangone.org.ORCID http://orcid.org/0000-0002-3100-4800

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
Thalamocortical cognitive networks in the healthy human brainP50MH132642 · NIMH · PRINCETON UNIVERSITY · PI SABINE KASTNER · 2023 to 2026
$15.7M
Transformation of Neuronal Activity in the Entorhinal-hippocampal-neocortex PathR01MH122391 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BASU, JAYEETA, BUZSAKI, GYORGY · 2020 to 2024
$3.3M
CRCNS: Dissection and control of cognitive thalamocortical dynamicsR01MH139352 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Zhe Sage Chen, Michael M Halassa · 2024 to 2026
$1.4M
Consolidation and interference of hippocampal spatial mapsR01MH139216 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GYORGY BUZSAKI, KAMRAN DIBA · 2025 to 2026
$1.2M
Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.RF1DA056394 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, CHEN, ZHE SAGE · 2022 to 2022
$1.1M
NIDA NIH HHS RF1 DA056394NIMH NIH HHS P50 MH132642NIMH NIH HHS R01 MH122391NIMH NIH HHS R01 MH139216NIMH NIH HHS R01 MH139352NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

The capacity of hippocampal circuits to transform inputs into downstream outputs is fundamental to navigation and memory, yet the circuit-level mechanisms that enable this flexibility in adapting to experience remain unclear. Here we approach this problem by performing large-scale (up to 1,024 channel) recordings across the hippocampal-retrosplenial cortex (RSC) circuit in behaving mice, enabling simultaneous access to spiking activity in dentate gyrus (DG), CA3, CA2, CA1 and RSC. On the basis of a linear dimensionality-reduction technique known as partial canonical correlation analysis, we identify low-dimensional communication subspaces

Indexed as

Cerebral CortexGyrus CinguliHippocampusNeural PathwaysAction PotentialsAnimalsCA1 Region, HippocampalCA3 Region, HippocampalDentate GyrusMaleMiceMice, Inbred C57BLNeurons

Identifiers

PMID42129569
PMCPMC13317024

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.