Evidence map›Paper›PMID 42129565›Full record

ArticleNature2026

Eosinophils drive intestinal remodelling and innate defence in reproduction.

Chenyan Huang, Amanda Sun, Jojo Reyes, Jessica Ribeiro de Souza, Thomas R Cafiero, Krist H Antunes Fernandes, Fabricio Marcus Silva Oliveira, Yujie Qiao, Pedro Gazzinelli-Guimaraes, Yuri Pritykin and 1 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenyan Huang *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Amanda Sun *Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-7002-7263
Jojo ReyesDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Jessica Ribeiro de SouzaDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Thomas R CafieroDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-4365-8430
Krist H Antunes FernandesDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Fabricio Marcus Silva OliveiraDepartment of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Yujie QiaoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0009-7182-2355
Pedro Gazzinelli-GuimaraesDepartment of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Yuri PritykinLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-6589-981X
Ai Ing LimDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. aiinglim@princeton.edu.ORCID http://orcid.org/0000-0001-8834-3136

Funding

Methods and Logic in Molecular Biology Training ProgramT32GM148739 · NIGMS · PRINCETON UNIVERSITY · PI Ileana M. Cristea · 2023 to 2026
$3.6M
Regulatory genomics of T cells in mouse and humanDP2AI171161 · NIAID · PRINCETON UNIVERSITY · PI Yury Pritykin · 2022 to 2026
$2.4M
NIAID NIH HHS DP2 AI171161NIGMS NIH HHS T32 GM148739
6 · The paper itself

Abstract

Mammalian reproduction requires substantial immune adaptations to safeguard reproductive success and to ultimately shape the evolutionary trajectories of a species. Systemic and placental immunity shift towards tolerance during pregnancy

Indexed as

EosinophilsImmunity, InnateIntestinesIntestine, SmallReproductionAnimalsCell DifferentiationFemaleGoblet CellsIntestinal Barrier FunctionLactationMiceMice, Inbred C57BLMucusPregnancy

Identifiers

PMID42129565
PMCPMC13233317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.